Nullsoft's free NSIS installer system is really easy to customize. Or
you can use a wizard to do all the work for you. It even creates
uninstallers and can confirm that QuickTime is installed (for
jitter/softvns apps). Totally free.
"astrium install wizard" is something we use to make XP installers. i
don't handle that part, but the person who does likes it (he tried many
others before deciding on this one).