s2m.wacom

yes, [s2m.wacom] has a 'nopointer' message that decouples the pen movement from the system cursor. I used the Intuos 3 with the [s2m.wacom] for a long time on my old machine and it worked very reliably. Be aware, though, that the current wacom driver doesn't support the Intuos 3 anymore. You might be lucky and find an old version that still supports it and works on your machine. (version 6.3.15-3 worked for me on an intel-based mac).
But there are still more troubles:
Around the introduction of 'Catalina' security issues started to become a major problem. [s2m.wacom] couldn't communicate with the wacom driver anymore because automation processes, like sending Apple events, are blocked now by default. This renders messages like 'nopointer' non-functional. AFAIK this issue is still not resolved (at the moment I'm working on an updated version of [s2m.wacom] for arm64 (M1) and face the exact problem of blocked Apple events).